Monte Rosa Receives $50M Milestone for Phase 2 Study
Monte Rosa Therapeutics announced a $50 million milestone payment from Novartis following the initiation of a Phase 2 clinical study for its Sjogren's disease treatment candidate.
Latest equities, bonds, and regulatory news from United States, updated daily.
The United States securities market is supervised by the Securities and Exchange Commission, a federal agency whose stated mission is to protect investors, maintain fair, orderly, and efficient markets, and facilitate capital formation. The Commission has up to five Commissioners appointed by the President with the advice and consent of the Senate, and no more than three of them may belong to the same political party. Below the Commission sit self-regulatory organisations that write and enforce their own rulebooks under SEC review, including the Financial Industry Regulatory Authority, the Municipal Securities Rulemaking Board and the Public Company Accounting Oversight Board, alongside the Securities Investor Protection Corporation and the Financial Accounting Standards Board.
The scale of what that machinery covers is set out in the SEC’s fiscal 2026 congressional budget justification. The agency reports oversight of more than 33,000 entities, among them 26 national securities exchanges, more than 3,300 broker-dealers, 109 alternative trading systems, 318 transfer agents, 6 active registered clearing agencies, more than 13,500 registered funds and more than 15,900 investment advisers. The same document puts the reporting population at more than 7,400 companies whose disclosure and financial statements the staff reviews, and describes the markets under supervision as totalling more than $100 trillion. The figures for exchanges, broker-dealers and transfer agents are stated as of FY 2024.
Trading is fragmented across those 26 exchanges and the alternative trading systems, but the day is organised around the primary listing venues’ auctions. The New York Stock Exchange runs an Early Trading Session from 7:00 a.m. to 9:30 a.m. Eastern time, a Core Trading Session from 9:30 a.m. to 4:00 p.m. opened by the Core Open Auction, a Closing Imbalance Period from 3:50 p.m., a Closing Auction at 4:00 p.m., and a Late Trading Session to 8:00 p.m. Settlement is one business day after the trade. The Commission adopted the shortening from T+2 to T+1 on Feb. 15, 2023, with a compliance date of May 28, 2024, and paired it with same-day allocation, confirmation and affirmation requirements and straight-through processing obligations on central matching services.
Equities share the market with the largest government bond programme in the world. Treasury’s Debt to the Penny series put total public debt outstanding at $40,112,464,593,206.30 on 2026-09-01, of which $32,420,529,452,197.11 was held by the public. The Office of Debt Management reported total receipts of $4,151 billion and total outlays of $5,518 billion through Q3 FY2026, projected privately-held net marketable borrowing of $739 billion for Q4 FY2026 against an assumed end-of-quarter cash balance of $950 billion, and noted that all primary dealers expected no changes to nominal coupon, TIPS or floating rate note issuance sizes at the August refunding.
Index construction is a private, published discipline rather than a state function. The Nasdaq-100 Index measures 100 of the largest Nasdaq-listed non-financial companies on a modified market capitalisation weighting, restricts membership to companies primarily listed on a U.S. Nasdaq-affiliated exchange, excludes anything classified in the Financial Industry under the Industry Classification Benchmark, and rules out real estate investment trusts, special purpose acquisition companies and when-issued securities. GSN covers this market through company filings and exchange announcements, Commission rulemaking and enforcement, and Treasury issuance.
Sources
This overview is based on the official documents listed below, last checked 2026-09-03. Figures are as stated in those documents.
Milestone Pharmaceuticals (Nasdaq: MIST) announced China's regulatory approval of etripamil nasal spray for heart rhythm disorder, marking the first approval of the drug outside the United States.
Monte Rosa Therapeutics announced a $50 million milestone payment from Novartis following the initiation of a Phase 2 clinical study for its Sjogren's disease treatment candidate.
Roivant Sciences will present topline results from its Phase 2 PHocus study of mosliciguat in patients with pulmonary hypertension associated with interstitial lung disease at the ERS Congress 2026.
Star Bulk Carriers Corp. announced a parallel listing on Euronext Athens and an equity offering in Greece to raise capital.
ACI Worldwide has agreed to acquire Cranium Ventures and its SYNAP card switching framework for ACI Connetic. Terms were not disclosed and the deal is expected to close by the end of September.
UniFirst Corporation (NYSE: UNF) has introduced a new workwear line designed for mobility and comfort, targeting the active frontline workforce.
Aficamten met both primary endpoints in the first Phase 3 trial to succeed in non-obstructive hypertrophic cardiomyopathy, and Cytokinetics plans a supplemental FDA filing in the fourth quarter.
Navitas Semiconductor announced a definitive agreement to acquire Claros to expand its grid-to-xPU power delivery capabilities for AI data centers.
Bleichroeder Acquisition Corp. II shareholders approved the Pasqal business combination on August 25, 2026 and the deal closed two days later. Holders of 26,039,602 of 28,750,000 public shares redeemed.
The first of two pivotal wet AMD trials failed its primary visual acuity endpoint in the full dataset; EyePoint points to secondary endpoints and an ad hoc analysis excluding nine patients.
Newbury Street II Acquisition Corp announced a definitive business combination agreement with FORT Robotics to create a publicly traded entity focused on physical AI safety.
Fernando Queiroz, CEO of Levona Renewables, writes that transmission and interconnection work now consume more of his team's time than solar equipment does on a recent ERCOT-zone project.
In a shareholder letter filed with the SEC, Nexscient said its April acquisition of Flipside AI turned it into an operating business and outlined new AI data clients and Nasdaq uplisting plans.
Parsons, an engineering and construction services firm, has been selected to provide project management and construction management services for a major airport terminal renovation in Knoxville.
Rocket Lab filed pro forma and historical financial statements tied to its pending acquisition of satellite operator Iridium Communications, detailing deal terms and a $3.6 billion bridge loan.
Serve Robotics, a San Carlos-based autonomous delivery company, disclosed a Grubhub partnership, two new markets, and a next-generation hospital robot in an August 17 SEC filing.
Babcock & Wilcox will supply 20 Siemens Energy steam turbine generator sets totaling 1 gigawatt of capacity for its FastPower data center program, the company said.
Comstock's second-quarter filing sets out the cost, permitting status and rated capacity of the Silver Springs solar panel recycling plant, and the mining sale that funds it.
An amended SEC filing that corrects a slide in the company's investor presentation discloses second-quarter revenue growth, design wins, and third-quarter guidance.
Ondas Inc. said it has closed its previously announced acquisition of drone inspection firm Cyberhawk, expanding into critical infrastructure intelligence.
The connected-fleet software company reported first-quarter results, updated fiscal 2027 guidance, and named a new president and CFO plus a chief AI officer.
Rocket Lab reported record second-quarter 2026 revenue of $234 million and a record $2.36 billion backlog, and guided to another record revenue quarter in Q3.
The Seattle-based cell therapy company posted second-quarter 2026 financial results alongside clinical progress on its diabetes and lymphoma programs and a new Mayo Clinic collaboration.
Ichor Holdings posted second-quarter 2026 revenue of $294.8 million, up 15% sequentially, swung to GAAP profitability, and guided to further growth for the third quarter.
Shentel posted 5.5% revenue growth in the second quarter of 2026 as its Glo Fiber expansion segment grew 32.8% and the company reiterated full-year guidance.
Momentus told investors its Vigoride 8 mission is fully booked with two NASA payloads for 2027. The same filing shows $107.6 million of cash after $109.9 million of net financing in the first half.
Nauticus Robotics said it completed the first prototype of a compact electric subsea manipulator. Its second-quarter filing confirms the build and shows service revenue down 57% year on year.
Microbot Medical says LIBERTY robotic system drove more than 100% quarter-over-quarter growth in revenue and customers in Q2 2026, alongside new hospital adoptions, a federal supply agreement, and its first clearance outside the US.
NewHydrogen, Inc. said it is automating its Engineering Test Unit to support development of its ThermoLoop hydrogen technology, aiming for round-the-clock testing ahead of a planned pilot plant.
Guidance and consensus estimates sound like the same yardstick, but they are built differently, updated differently, and can send opposite signals in the same earnings report.
Lock-up agreements keep insiders and early investors from selling shares for months after an IPO. Here's how these contracts work and what happens mechanically when they expire.
A bond ladder strategy involves purchasing bonds with staggered maturity dates to create a predictable income stream and manage interest rate risk. This educational overview explains how this market mechanism works for fixed income investors.
How SEC Regulation NMS forces brokers and exchanges to route orders to the best displayed price, and what actually counts as a trade-through violation.
Some US corporate and municipal bonds can be paid off years before maturity, at the issuer's choice alone. Here is how call provisions, call prices and make-whole premiums actually work.
A structural look at how short sellers locate and borrow shares, track short interest and days to cover, and eventually close out a position, including the risk of a forced buy-in.
Behind every tender offer headline is a specific number: the premium over the recent trading price. Here is the mechanics of how that figure gets built.
A single ticker can stop trading for hours while the rest of the market carries on as usual, and understanding why reveals two very different regulatory tools at work.
A single comment letter rarely moves a regulator. Here is the quiet, multi-year process that actually determines when a securities watchdog reopens an existing disclosure rule.
A bond's stated yield tells you almost nothing about how much its price will move when rates change. Duration does. Here is what the number actually captures.
A new bond issue leaves a precise public record the moment it is priced. Here is what the SEC and FINRA rulebooks show about how that price is set, disclosed and reported.
Every few months, thousands of public companies report results within the same few weeks. Here is why that clustering happens and how the calendar behind it actually works.
A company can announce a multi-billion-dollar buyback authorization and repurchase almost none of it. Here is how boards actually set that ceiling, and why it is a permission slip, not a promise.
A price range printed on a prospectus is a starting point, not a forecast. Here is what happens in the weeks before underwriters lock in the number investors actually pay.
Tender offers and open-market buybacks both shrink a company's share count, but their legal structure, pricing, and timeline work in almost opposite ways.
A trader can legally act on a hunch but not on a boardroom memo. The line between the two defines one of the most misunderstood rules in finance.
A private company can reach a public listing through a traditional IPO or by merging with a special purpose acquisition company. The destination looks similar, but the process, the disclosure regime, and the timeline diverge sharply.
A downgrade changes an opinion, not a business. SEC filings and staff findings show where it becomes real: collateral clauses, fund mandates and index rules, and a spread move that has usually already happened.
A stock sits flat all session, yet the options tied to it swing in value. The explanation lies not in direction but in a separate force: implied volatility.
Form 10-K and Form 10-Q run on different item lists, different accounting rules and different clocks, and a company's public float decides which deadline and which scaled disclosures apply.
Rule 10b-18 sets how an issuer may buy its own shares, Item 703 sets what it must publish afterwards, Delaware law sets whether it may buy at all, and a federal excise tax prices the whole exercise.
Regulation FD, Regulation G and the statutory safe harbor decide the order of events on an earnings call, which numbers must be reconciled, and how the outlook has to be worded.
A stock trades thousands of times a second with barely a ripple in price. Behind that smoothness sits a quiet, highly regulated business built on pennies, speed, and risk.